Strontium Substituted Tricalcium Phosphate Bone Cement: Short and Long‐Term Time‐Resolved Studies and In Vitro Properties

Due to a significant influence of strontium (Sr) on bone regeneration, Sr substituted β-tricalcium phosphate (Sr-TCP) cement is prepared and investigated by short- long-term time-resolved techniques. For short-term investigations, energy-dispersive X-ray diffraction, infrared spectroscopy, and, for the first time, terahertz time-domain spectroscopy techniques are applied. studies, angular dispersive scanning electron microscopy, mechanical tests, behavior in Ringer solution carried out. After 45 min setting, Sr-TCP phase no longer detectable. During this time period, an appearance constant increase final brushite registered. The compressive strength increases from 4.5 MPa after 2 h setting reaches maximum at 13.3 21 d. soaking d solution, apatite product, with admixture TCP phases detected. cytotoxicity aspects using NCTC 3T3 fibroblast cell line, cytocompatibility—by human dental pulp mesenchymal stem cells. obtained results allow conclude that developed promising biomedical applications tissue.